Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients

Completed

• Conditions: Hyperhomocysteinemia; Cardiovascular Disease

• Registration Number: NCT01391416
• Lead Sponsor: Bangkok Metropolitan Administration Medical College and Vajira Hospital

Brief Summary

It is well recognized that patients with chronic kidney disease (CKD) have an increased risk for cardiovascular disease (CVD) and hyperhomocysteinemia appears to be a predictor of future CVD events. Hyperhomocysteinemia has been reported to bo of high prevalence in patients with CKD. The investigators aim to study the prevalence of hyperhomocysteinemia in Thai CKD patients by using Thai Screening and Early Evaluation of Kidney Disease (SEEK) study database and their relationship to CVD.

Detailed Description

Ninety eight subjects were sampling from Thai SEEK study database Traditional Traditional risk factors of CVD such as total cholesterol, triglyceride, age, sex, history of smoking and blood pressure levels were examined and recorded. Stored sera of these subjects were analyzed for the total homocysteine (tHcy) level. Analysis of variance was used to evaluate the different of mean tHcy among groups

Study Timeline

• Status Verified: 2010-05
• Study Start: 2010-06
• Primary Completion: 2010-11
• Study Completion: 2011-01
• Study First Submitted: 2011-07-08
• Study First Submitted QC: 2011-07-11
• Last Update Submitted: 2011-07-11
• Study First Posted: 2011-07-12
• Last Update Posted: 2011-07-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• CKD stages 3-4 from Thai SEEK Study

Exclusion Criteria

• CKD stage 5

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Level of Homocysteine	3 months	Level of homocysteinemia according to each CKD level

Secondary Outcome Measures

Name	Time	Method
Association of cardiovascular event to the level of homocysteine	3 months	Hugh level of homocysteine will have association with cardiovascular events or not