Target-controlled propofol infusion anaesthesia provides better immediate anaesthesia outcome than desflurane anaesthesia in liver transplantation patients

Not Applicable

Completed

• Conditions: Associated patient outcome in deceased or living donor liver transplantation recipients who received TIVA with propofol anesthesia versus desflurane anesthesia; Anaesthesiology - Anaesthetics; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12612000305820
• Lead Sponsor: Chueng-He Lu

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-03-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

All the liver recipients who received total intravenous anesthesia with propofol or desflurane anesthesia operated at Tri-Service General Hospital from September 2007 to August 2010.

Exclusion Criteria

Patients were excluded if they met any of the following criteria: presence of encephalopathy, requirements for pretransplant endotracheal intubation/mechanical ventilation, or use of vasopressors before transplantation.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
orepinephrine use during reperfusion as assessed by medical records.<br>After reperfusion, bolus of norepinephrine was used to keep mean arterial pressure above 60 mmHg or within 30% of pre-reperfusion systolic arterial pressure.[During reperfusion period (via paper medical records)]

Secondary Outcome Measures

Name	Time	Method
Postoperative recovery outcomes: awake time[at any time during the study period (via electronic/paper medical records)];Postoperative recovery outcomes: extubation time[at any time during the study period (via electronic/paper medical records)];Alanine aminotransferase (ALT) concentration[24 hours after transplantation];Postoperative recovery outcomes: intensive care unit (ICU) stay[at least 60 days after surgery (via electronic/paper medical records)];Postoperative recovery outcomes: days in hospital[at least 60 days after surgery (via electronic/paper medical records)]