Retrospective, monocentric study for comparative analysis of postoperative results after CyPass implantation with and without bevacizumab (intracameral) for wound healing modulatio

• Conditions: H40.1; Primary open-angle glaucoma

• Registration Number: DRKS00013987
• Lead Sponsor: Klinik für Augenheilkunde, Dietrich-Bonhoeffer-Klinikum,

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-09-29
• Study Start: 2018-12-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 313

Inclusion Criteria

Patients with primary chronic open angle glaucoma
- Implantation of the CyPass stent at the Department of Ophthalmology at the Dietrich-Bonhoeffer-Klinikum Neubrandenburg between March 2009 and September 2016
- data of follow-up visits available after 3 and 6 months
- Patient age =18 years

Exclusion Criteria

- surgery canceled
- more than 3 hours difference in the time of pre- and postoperative intraocular pressure measurement
- Additional exclusion criterion for the evaluation of the data concerning the effectiveness:
-- postoperative rTPA injection

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The main question is the retrospective data analysis to determinate the efficacy of supplemental intracameral bevacizumab (= Avastin) injection after CyPass microstent implantation (2009-2016) on the intraocular pressure and the postoperative number of hypotensive local drugs.

Secondary Outcome Measures

Name	Time	Method
The auxiliary question is te retrospective analysis to determine the safety of the additional injection of Bevacizumab (=Avastin) into the anterior chamber based on slit-lamp microscopic findings compared to CyPass implantation without Avastin postoperative (2009-2016).