High Flow Nasal Canula Oxygen Helps Preoxygenate ARDS Patients

Completed

• Conditions: Acute Respiratory Distress Syndrome

• Registration Number: NCT02214576
• Lead Sponsor: Hôpital Louis Mourier

Brief Summary

Tracheal intubation in the ICU is associated with significant complications and morbidity. Desaturation is among the most frequent and hazardous complication, occurring in almost one out of four intubations, that may in some instances lead to cardiac arrest; despite appropriate preoxygenation. Non-invasive ventilation may help improve preoxygenation but does not allow for apneic oxygenation and may not be performed in patients with neurological impairment. High flow nasal canula oxygen is increasingly used in the ICU in patients with acute hypoxemic respiratory failure and may be used to improve preoxygenation. It is currently used in our ICU for that purpose. Because high flow nasal canula oxygen is our first line oxyten therapy for patients with acute respirtory distress syndrome, we sought to determine its use as a means to ensure preoxygenation in those ARDS patients that require intubation.

Detailed Description

High flow nasal canula oxygen is increasingly used to provide heated and humidified oxygen in patients with acute respiratory failure. One of the major advantages of high flow nasal canula oxygen is the possibility to maintain oxygenation during laryngoscopy and thereby providing high flow apneic oxygenation. In addition, and contrary no non-invasive ventilation, preoxygenation may be used in patients with neurological impairment. Finally, the interest of this device is that it is the same that is maintained throughout the whole management of the patient, from ICU admission to intubation.

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2014-08-11
• Study First Submitted QC: 2014-08-11
• Study First Posted: 2014-08-12
• Status Verified: 2015-08
• Primary Completion: 2015-08
• Study Completion: 2015-08
• Last Update Submitted: 2015-08-13
• Last Update Posted: 2015-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• ARDS according to the Berlin criteria
• use of high flow nasal canula oxygen

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oxygen saturation	30 minutes	oxygen saturation measured by pulse oxymetry during intubation and compared to levels before intubation

Secondary Outcome Measures

Name	Time	Method
complications	60 minutes	arrhythmia, hypotension, profound desaturation, cardiac arrest

Trial Locations

Locations (1)

Medico-surgical ICU, Louis Mourier Hospital; 🇫🇷 Colombes, France