To study the effect of oxygen therapy given at very high rate in patient with sudden onset of breathing failure.
- Conditions
- Health Condition 1: J960- Acute respiratory failure
- Registration Number
- CTRI/2018/09/015717
- Lead Sponsor
- Tata Memorial Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Age 18year and above
2.Respiratory rate of >25 breaths per minute
3.Ratio of the partial pressure of arterial oxygen (PaO2) to the fractional oxygen (FiO2) of 300 mm Hg or less while the patient breathing oxygen with oxygen analyzer in situ at a flow rate of 10 liters per minute for at least 15 minutes
1.The main exclusion criteria is PaCo2 >45 mm Hg,
2.Exacerbation of asthma or chronic respiratory failure,
3.Cardiogenic pulmonary edema,
4.A history of underlying chronic respiratory disease
5.Hemodynamic instability, use of vasopressors in a dose more than 0.25mcg/kg/min,
6.Glasgow Coma Scale score of 12 points or less
7.Contraindications to NIV
8.Urgent need for endotracheal intubation,
9.Palliative patients
10.Tracheostomy
11.Likelihood of Survival <72 hrs.
12.Patient with respiratory failure due to potentially irreversible causes e.g. Post radiotherapy fibrosis, Progression of Lung diseases etc
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method o of patients that will require endotracheal intubationTimepoint: between day 1 to 28 days after randomization
- Secondary Outcome Measures
Name Time Method 1 Number of ventilator free days (i.e., days alive and without invasive mechanical ventilation)Timepoint: between day 1 to day 28 after randomization;2 Mortality in the ICUTimepoint: at day 90 after randomization;3 Intubation rate in those with P/F ratios below 200Timepoint: between day 1 to day 28 after randomization;4 Intubation rate in neutropenic patientsTimepoint: between day 1 to day 28 after randomization;5 Total duration of ICU staysTimepoint: between day 1 to day 28 after randomization;6 Complication rates (e.g septic shock, nosocomial pneumonia, cardiac arrhythmia, and cardiac arrestTimepoint: between day 1 to day 28 after randomization;7 Grade of dyspneaTimepoint: between day 1 to day 28 after randomization