Effect of simvastatin on endothelial dysfunction, fibrinolysis, coagulation and inflammation after aneurysmal subarachnoid hemorrhage

Academic Medical Centre (AMC) (The Netherlands)0 个研究点目标入组 30 人开始时间: 2006年6月29日最近更新: 2015年1月13日

试验速览

暂无简介。

•1. Patients with clinical symptoms and signs of SAH with an aneurysmal bleeding pattern on the initial computerised tomography (CT) scan. CT scan has to be performed within 48 hours after SAH onset
•2. Patients with a perimesencephalic hemorrhage pattern on the initial CT scan while computed tomographic angiography (CTA) or conventional angiography has shown an appropriate aneurysm. CTA or angiography has to be performed within 48 hours after SAH onset
•3. If CT scan is negative while there is evidence of bleeding in the cerebrospinal fluid (xanthochromia) and the CT-angiography has shown an aneurysm

•1. Under 18 years of age
•2. A time lapse of more than 48 hours after SAH onset
•3. Patients using aspirin or warfarin
•4. Patients already using statins
•5. Contra-indication for simvastatin (active liver disease, liver transaminase more than three times the normal upper limit, myopathy)
•6. Kidney insufficiency
•7. If death appears imminent
•8. Pregnancy or lactation

发起方

Academic Medical Centre (AMC) (The Netherlands)