Fecal Microbiota Transplantation (FMT) for Intestinal Decolonization of Multidrug-resistant Opportunistic Pathogens
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multi-antibiotic Resistance
- Sponsor
- University of British Columbia
- Enrollment
- 90
- Locations
- 2
- Primary Endpoint
- The elimination of the target multi-drug resistant organism (MDRO), using culture and molecular test-based screening of recipient stool, at both the 14 and 30 days post-FMT.
- Last Updated
- 4 years ago
Overview
Brief Summary
This is a trial designed to determine whether fecal microbiota transplantation (FMT) can eliminate highly drug-resistant bacteria from the intestinal tract of renal transplant patients. The primary goal of this study is to test whether oral gut decontamination followed by FMT using enema delivery will result in decolonization of the intestinal tract of renal transplant patients shortly after solid organ transplantation, thereby preventing difficult to treat post-transplant infections.
Detailed Description
Contact the study principal investigator for the study protocol.
Investigators
Amee Manges
Associate Professor
University of British Columbia
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
The elimination of the target multi-drug resistant organism (MDRO), using culture and molecular test-based screening of recipient stool, at both the 14 and 30 days post-FMT.
Time Frame: 3 years
Secondary Outcomes
- Compare proportions, type and timing of adverse events post-FMT(3 years)
- Proportions of recolonization over 180 days(3 years)
- Timing of recolonization over 180 days(3 years)