Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- Maximum pain score over the first 24 hours after surgery
研究概览
简要总结
The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery.
The main questions are:
- Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia?
- Do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery?
- Do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?
详细描述
A patient's psychological profile importantly modulates pain severity, and the overall experience and impact of pain. For instance, catastrophic thinking about pain, including magnification, rumination, and helplessness, is associated with both greater pain severity and impact.
Over the years, regional anesthesia has become an integral part of multimodal pain management for many surgeries. Regional anesthesia (epidural and peripheral nerve blocks) to be associated with superior pain control, reduced time to return of bowel function, shorter intraoperative times, fewer side effects and complications, earlier ambulation and functional exercise capacity post-discharge, lower in-hospital mortality, reduced length-of-stay, improved patient satisfaction, and fewer readmissions.
The investigators aim to use of validated psychosocial surveys and semi-structured interviews to understand the phenotype of patients who will benefit the most from regional anesthesia. The investigators also aim to understand how different patient phenotypes and regional anesthesia affect perioperative opioid consumption, and development of chronic postsurgical pain.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •English speaking
- •Surgical or procedural patient who will be admitted postoperatively
- •Willingness to answer psychosocial survey and/or audio recorded semi-structured interview
排除标准
- •Cognitive dysfunction that precludes communication
结局指标
主要结局
Maximum pain score over the first 24 hours after surgery
时间窗: 0-24 hours
Maximum pain score (numerical pain rating score 0-10) over the first 24 hours after surgery
次要结局
- Average pain score over the first 24 hours after surgery(0-24 hours)
- Daily pain scores(0-7days)
- Worst pain score over the first 24 hours after surgery(0-24 hours)
- Least pain score over the first 24 hours after surgery(0-24 hours)
- Longitudinal pain scores(1-12 months)
- Postoperative opioid consumption(0-7 days)
- Incidence of chronic postsurgical pain(3-12 months)
研究者
Robert Edwards
Pain Psychologist
Brigham and Women's Hospital