Study of Molecular-genetic Profile of Thyroid Nodules
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 400
- Primary Endpoint
- Molecular profile of thyroid nodules
Study Overview
Brief Summary
Profiling and comparative analysis of genomic alterations and miRNA expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed. Obtained information is necessary to create a molecular test to refine the cancer risk of cytologically indeterminate thyroid nodules.
Detailed Description
This is an non-randomised retrospective study consisting of 2 parts. Part A. Histological specimens (formalin fixed paraffin embedded) of patients who were operated on for benign and malignant thyroid disorders will undergo molecular testing to create a molecular profile of thyroid nodules characteristic of Belarusian population.
Part B. Fixed cytological smears of indeterminate thyroid nodules (categories III, IV and V according to Bethesda scoring system) of operated patients will undergo molecular testing to evaluate the possibility and reliability of molecular testing of fixed cytological smears using available assays.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients operated on for malignant and benign thyroid tumors. Age is greater than or equal to 18 years old.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Molecular profile of thyroid nodules
Time Frame: 2 years
To develop a molecular profile of thyroid nodules that will allow to distinguish benign from malignant tumor
Secondary Outcomes
No secondary outcomes reported
Investigators
Siarhei Yakubouski
MD PhD Assistant Professor
Belarusian State Medical University