EUCTR2009-011881-27-DE
进行中（未招募）
不适用
Changes of cerebral spinal fluid APPSa levels under oral therapy with acitretin 30 mg daily in patients with mild to moderate Alzheimer’s disease: a multicenter prospective randomised placebo-controlled parallel-group study. - Alzheimer´s Disease Acitretin Medication (ADAM)
niversity Medical Center of the Johannes Gutenberg-University Mainz0 个研究点2010年1月20日
适应症Alzheimer’s diseaseMedDRA version: 14.1Level: LLTClassification code 10001896Term: Alzheimer's diseaseSystem Organ Class: 10029205 - Nervous system disordersTherapeutic area: Psychiatry and Psychology [F] - Mental Disorders [F03]
相关药物Neotigason
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Alzheimer’s disease
- 发起方
- niversity Medical Center of the Johannes Gutenberg-University Mainz
- 状态
- 进行中（未招募）
- 最后更新
- 11年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •mild to moderate AD (NINCDS\-ADRDA criteria)
- •MMSE according to Folstein: 27\-14 points
- •Geriatric Depression Scale \= 14
- •age \= 50 years
- •ability of subject to understand character and individual consequences of clinical trial
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 38
- •F.1\.3 Elderly (\>\=65 years) yes
排除标准
- •hereditary cognitive impairment
- •known history of brain injuries
- •Insufficient German language skills
- •actual treatment with other potential disease modifying drugs of AD
- •multimorbidity or significant organ (esp. liver or renal) dysfunction
- •evidence of Non\-AD neurodegenerative disorder (e.g. Parkinson)
- •contraindication to acitretin such as osteoporosis, hypoalbuminaemia
结局指标
主要结局
未指定
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