EUCTR2009-011881-27-DE进行中（未招募）不适用
Changes of cerebral spinal fluid APPSa levels under oral therapy with acitretin 30 mg daily in patients with mild to moderate Alzheimer’s disease: a multicenter prospective randomised placebo-controlled parallel-group study. - Alzheimer´s Disease Acitretin Medication (ADAM)
niversity Medical Center of the Johannes Gutenberg-University Mainz0 个研究点开始时间: 2010年1月20日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •mild to moderate AD (NINCDS-ADRDA criteria)
- •MMSE according to Folstein: 27-14 points
- •Geriatric Depression Scale = 14
- •age = 50 years
- •ability of subject to understand character and individual consequences of clinical trial
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 38
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 38
排除标准
- •hereditary cognitive impairment
- •known history of brain injuries
- •Insufficient German language skills
- •actual treatment with other potential disease modifying drugs of AD
- •multimorbidity or significant organ (esp. liver or renal) dysfunction
- •evidence of Non-AD neurodegenerative disorder (e.g. Parkinson)
- •contraindication to acitretin such as osteoporosis, hypoalbuminaemia
研究者
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