Effects of high intensity of inspiratory muscle training in patients with heart failure with mildly reduced and preserved ejection fraction: A randomized controlled trial

Faculty of Medicine, Chulalongkorn University0 个研究点目标入组 29 人开始时间: 2023年11月21日最近更新: 2024年8月19日

适应症

试验速览

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•1.Patients with symptoms and signs of chronic HF with a LVEF of more than 40% and no prior measurement of LVEF equal or less than 40% at baseline.
•2.Patients with NYHA class II or III.
•3.Patients with NT-pro BNP greater than 220 pg/dL or elevated LV filling pressure at rest or with exercise assessed by echocardiography.
•4.Patients who have been on a stable dose of HF medications for at least 4 weeks.

•1.Patients who are unable to perform a baseline exercise test: gait difficulty, orthopedic problems, etc. that affect their ability to walk.
•2.Patients who need intravenous diuretics, vasodilators, inotropic agents, or mechanical support within a week of screening, as well as during the screening period before randomization, and have acute decompensated HF.
•3.Patients with recent angina or open-heart surgery within 3 months prior to randomization.
•4.Patients with end-stage renal disease and require renal replacement therapy or kidney transplantation
•5.Patients with status post-heart transplantation
•6.Patients with anemia (Hb less than 10 g/dl)
•7.Patients with significant primary moderate to severe valvular disease.
•8.Patients with significant primary pulmonary disease, including pulmonary arterial hypertension, chronic thromboembolic pulmonary disease or chronic obstructive pulmonary disease.
•9.Patients who have systemic diseases such as amyloidosis or sarcoidosis.
•10.Patients with any other comorbidities with life expectancy less than 1 year.

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