Prevention of Post-Operative Atrial Fibrillatio

Completed

• Conditions: Post-operative atrial fibrillation; Circulatory System; Atrial fibrillation and flutter

• Registration Number: ISRCTN45347268
• Lead Sponsor: Fondo de Desarrollo Científico y Tecnológico (Chile)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09-02
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Aged between 30 - 80 years, either sex
2. Scheduled for elective coronary artery bypass graft, valve surgery, or mixed
3. In sinus rhythm

Exclusion Criteria

1. Previous heart surgery
2. Pre-operative documented history of chronic or paroxysmal AF
3. Comorbidities such as congenital or cardiac re-operation
4. Advanced hepatic disease (cirrhosis)
5. Chronic renal failure (serum creatinine greater than 2.0 mg/dL)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ocurrence of post-operative atrial fibrillation. Basal electrocardiogram for patients in sinus rhythm and electrocardiographic monitoring will be performed throughout the hospitalisation period, in order to detect the occurrence of atrial fibrillation.

Secondary Outcome Measures

Name	Time	Method
1. Biochemical markers of oxidative stress, performed on blood samples withdrawn: 7 and 2 days before surgery, the day of surgery, 8 hours and 4 days after surgery<br>2. Atrial tissue will be obtained during surgery to be analysed