Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea

Not Applicable

Completed

• Conditions: Obstructive Sleep Apnea; Atrial Fibrillation; Coronary Artery Bypass Grafting
• Interventions: Device: CPAP

• Registration Number: NCT02737215
• Lead Sponsor: Rodrigo Pinto Pedrosa

Brief Summary

Background. Atrial fibrillation is one of the most common complications in the postoperative period of coronary artery bypass grafting (CABG) surgery and usually associated with increased length of hospital stay and higher hospital costs. Among the main mechanisms involved, excessive sympathetic activation, oxidative stress and inflammation are fundamental elements in the pathophysiology of obstructive sleep apnea. Objectives. To evaluate the effects of continuous positive airway pressure (CPAP) in reduction of atrial fibrillation after CABG in patients with obstructive sleep apnea. Methodological procedures: A multicenter randomized controlled study to compare the incidence of atrial fibrillation between the intervention group and the control group, both monitored seven days with Holter.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-04-10
• Study First Submitted QC: 2016-04-10
• Study First Posted: 2016-04-13
• Study Start: 2016-05-02
• Primary Completion: 2019-12
• Study Completion: 2019-12
• Status Verified: 2021-12
• Last Update Submitted: 2021-12-01
• Last Update Posted: 2021-12-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 144

Inclusion Criteria

• apnea-hypopnea index > 15 events/hour

Exclusion Criteria

• ejection fraction < 45%
• chronic atrial fibrillation
• periprocedural instability (haemodynamic, neurological)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CPAP group	CPAP	patients will receive CPAP therapy for the first 7 days after extubation from CABG

Primary Outcome Measures

Name	Time	Method
atrial fibrillation	first 7 days after CABG	will be verified by holter monitoring

Trial Locations

Locations (3)

Instituto de Medicina Integral Prof Fernando Figueira - Imip; 🇧🇷 Recife, Pernambuco, Brazil

Pronto Socorro Cardiológico de Pernambuco - Procape; 🇧🇷 Recife, PE, Brazil

INCOR - Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo; 🇧🇷 Sao Paulo, SP, Brazil