Control and Reward Circuits in Obsessive Compulsive Disorder

Not Applicable

Completed

• Conditions: Obsessive-Compulsive Disorder
• Interventions: Behavioral: Exposure & Response Prevention (EX/RP)

• Registration Number: NCT02221518
• Lead Sponsor: New York State Psychiatric Institute

Brief Summary

The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.

Detailed Description

The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. We will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future transdiagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new transdiagnostic treatments.

Study Timeline

• Study First Submitted: 2014-08-18
• Study First Submitted QC: 2014-08-19
• Study First Posted: 2014-08-20
• Study Start: 2014-10
• Primary Completion: 2018-06
• Study Completion: 2018-08
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-12
• Last Update Posted: 2019-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with OCD	Exposure & Response Prevention (EX/RP)	Behavioral: Exposure \& Response Prevention (EX/RP)

Primary Outcome Measures

Name	Time	Method
Change from baseline in brain activation (fMRI) and fractional anisotropy (Diffusion tensor imaging) after therapy	Baseline & approximately 10 weeks later

Secondary Outcome Measures

Name	Time	Method
Change in reaction times and correct responses on Stop signal reaction time task	Baseline and approximately 10 weeks later, at second scan

Trial Locations

Locations (1)

NY State Psychiatric Institute; 🇺🇸 New York, New York, United States