Control & Reward Circuits as Targets for Repetitive Thoughts and Behaviors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obsessive-Compulsive Disorder
- Sponsor
- New York State Psychiatric Institute
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Change from baseline in brain activation (fMRI) and fractional anisotropy (Diffusion tensor imaging) after therapy
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.
Detailed Description
The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. We will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future transdiagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new transdiagnostic treatments.
Investigators
Helen Blair Simpson
Professor of Psychiatry-Columbia University Medical Center, Columbia University; Director of Anxiety Disorders Clinic & Center for OCD and Related Disorders
New York State Psychiatric Institute
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change from baseline in brain activation (fMRI) and fractional anisotropy (Diffusion tensor imaging) after therapy
Time Frame: Baseline & approximately 10 weeks later
Secondary Outcomes
- Change in reaction times and correct responses on Stop signal reaction time task(Baseline and approximately 10 weeks later, at second scan)