Contrast-enhanced Ultrasound (CEUS) for determining muscular Perfusion after oral intake of L-Citrulline, L-Arginine, and galloylated epicatechines.
- Conditions
- Examination of different sport supplement ingredients for their potency of vasodilation in skeletal muscle.
- Registration Number
- DRKS00016972
- Lead Sponsor
- niversität Heidelberg, Zentrum für Orthopädie, Unfallchirurgie und Paraplegiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 30
Young male subjects who workout in athletic sports regularly (e.g. Fitness/Gym, weightlifting, powerlifting)
• Existing contraindications for contrast agent
o Known intolerance for SonoVue® or other ultrasound contrast agents
o Cardiac Right-to-left shunt
o severe heart failure (NYHA III and IV)
o uncontrollable hypertension
o severe pulmonary hypertension(>90 mmHg)
o acute respiratory distress syndrome
o taking Dobutamine while suffering cardiovascular instability
o severe pulmonary diseases, in particular severe obstructive pulmonary diseases, ARDS.
• Known diseases of the vascular system, liver, kidneys or gastrointestinal tract
• smokers
• Regular consumption of L-Citrulline, L-Arginin, or Vaso6™ within the last 7 days before CEUS-examination
• Consumption of caffeine or nicotine within the last 12 hours before CEUS-examination
• physical workout within the last 24 hours before CEUS-examination
• adults incapable of consent, missing letter of agreement, or rejection of participation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Perfusion of Musculus biceps brachii before and after exercise plus during influence of described Supplement ingredients (see Arm1-3)<br>Measured by Contrast-enhaced Ultrasound (ECEUS)
- Secondary Outcome Measures
Name Time Method Comparing intensities of cumulative perfusion among each ingredient.