Genotype-related Molecular Targets in the Vitamin D Pathway for Spinal Disc Diseases
- Conditions
- Intervertebral Disk Degeneration
- Registration Number
- NCT03343899
- Lead Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
- Brief Summary
The objective of our study will be to analyze the interplay between particular VDR variants and its ligand in cells obtained from intervertebral disc and cartilage endplate and their action on cell proliferation and phenotype maintenance. The identification of novel molecular targets in the vitamin D pathway, potentially promoting pathological alterations of the tissues involved in spinal disc diseases, will allow to develop innovative and more personalized preventive and pharmacological/nutritional therapies.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 15
patients with spinal disc diseases
- males and females
- 18≤age ≤ 70 years old
- Italian white
- patients with spinal disc diseases that will be surgically treated
Exclusion criteria:
- age < 18 or > 70 years old
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Phenotype and genotype characterization 1 year To evaluate structural alterations of the intervertebral disc and of the cartilage endplate in patients with spinal disc diseases related to functional FokI polymorphism in the vitamin D receptor (VDR) gene.
- Secondary Outcome Measures
Name Time Method Disc cell functional response genotype-based 2 years To characterize cells obtained from different disc tissues (nucleus pulposus, annulus fibrosus, cartilage endplate) and to evaluate their VDR FokI genotype-related response to vitamin D treatment, regulating the cell proliferation and phenotype.
Trial Locations
- Locations (1)
Alessandra Colombini
🇮🇹Milan, Italy