Sugammadex Reversal of Neuromuscular Blockade and Postoperative Bleeding
Not Applicable
- Conditions
- Blood Coagulation Tests ( INR, APTT)
- Interventions
- Drug: Intravenous neostigmine and atropine
- Registration Number
- NCT02939430
- Lead Sponsor
- Mansoura University
- Brief Summary
Sugammadex is new drug that is used for reversal of rocuronium induced muscle relaxation. benefits of reversal of neuromuscular blockade appears to be of great value in living donor liver transplant recipients. However, Few Clinical reports have investigated the anticoagulant effect of sugammadex. In this study, effects of sugammadex on bleeding profile of living donor liver transplantation will be investigated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- all candidates for living donor liver transplantation
Exclusion Criteria
- massive intraoperative bleeding manifestations of early graft dysfunction
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Intravenous neostigmine and atropine Reversal of neuromuscular blockade will be performed using classic drugs (neostigmine 80 mic/kg and atropine 40 mic/kg) Sugammadex group Sugammadex intravenous Reversal of neuromuscular blockade will be performed using Sugammadex 2mg/kg
- Primary Outcome Measures
Name Time Method activated partial thromboplastin tile in seconds 30 min
- Secondary Outcome Measures
Name Time Method international normalized ratio in second 30 min
Trial Locations
- Locations (2)
Mansoura university
🇪🇬Mansoura, Dkahleya, Egypt
Gastroenterology center
🇪🇬Mansoura, Egypt