External Oblique Intercostal Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Adult Patients Undergoing Open Nephrectomy

Not Applicable

Recruiting

• Conditions: Transversus Abdominis Plane Block; Postoperative Analgesia; External Oblique Intercostal Plane Block; Nephrectomy
• Interventions: Other: External Oblique Intercostal Plane Block; Other: Transversus Abdominis Plane Block

• Registration Number: NCT06452238
• Lead Sponsor: Tanta University

Brief Summary

The aim of this study is to compare external oblique intercostal plane (EOIP) block and ultrasound guided transversus abdominis plane (TAP) Block for postoperative analgesia in adult patients undergoing open nephrectomy.

Detailed Description

Patients undergoing nephrectomy have a high incidence of postoperative pain despite the use of modern laparoscopic surgical techniques. In the postoperative period, these patients are often treated with patient-controlled opioids, epidural analgesia, or both.

Ultrasound-guided transversus abdominis plane (TAP) block is a relatively new technique to infiltrate regional anesthesia in which local routine anesthetics are injected between the internal oblique and transverse abdominal muscles. Studies have confirmed that ultrasound-guided (USG) transversus abdominis plane (TAP) block is an effective method of analgesia for upper abdominal surgeries, lower abdominal surgeries, and kidney transplantation, with minimal side effects.

External oblique intercostal plane block (EOIPB) has been reported by Elsharkawy et al. in 2021 as a significant modification of fascial plane blocks in that it may engage the upper lateral abdominal walls consistently. In comparison to quadratus lumborum block (QLB) and erector spinae plane block (ESPB) , The advantage of EOIPB is that it may be performed with the patient supine. Furthermore, in comparison to serratus intercostal plane block (SIPB), it generates more extensive analgesic effects throughout the whole midline of the abdomen .

Study Timeline

• Study First Submitted: 2024-05-30
• Status Verified: 2024-06
• Study First Submitted QC: 2024-06-04
• Study First Posted: 2024-06-11
• Study Start: 2024-06-12
• Last Update Submitted: 2024-06-12
• Last Update Posted: 2024-06-13
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age ≥ 18 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Scheduled for open nephrectomy.

Exclusion Criteria

• Bleeding disorders.
• Skin lesions or infection at the site of proposed needle insertion.
• Allergy to local anesthetics.
• Neurological disorders.
• Drug abuse.
• BMI > 30 kg/m2.
• Pregnancy.
• Diabetic neuropathy.
• Severe cardiovascular problems.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
External Oblique Intercostal Plane Block	External Oblique Intercostal Plane Block	Patients will receive external oblique intercostal plane block .
Transversus Abdominis Plane Block	Transversus Abdominis Plane Block	Patients will receive ultrasound guided transversus abdominis plane block.

Primary Outcome Measures

Name	Time	Method
Total pethidine consumption in the 1st 24hr	24 hours postoperatively	A standardized analgesic regimen will be prescribed in the postoperative period. All patients will receive paracetamol 1 gm every 6 h as routine analgesia. Rescue analgesia of pethidine will be given as 2 mg bolus if the Numerical Rating Scale (NRS) \> 3 to be repeated after 30 min if pain persists until the Numerical Rating Scale (NRS) \< 4. NRS will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.

Secondary Outcome Measures

Name	Time	Method
Mean arterial pressure	Every 15 minutes till the end of surgery	It will be recorded preoperative, before performing of block, and every 15 min till the end of surgery.
Heart rate	Every 15 minutes till the end of surgery	It will be recorded preoperative, before performing of block, and every 15 min till the end of surgery.
Intraoperative fentanyl consumption	Intraoperatively	Additional fentanyl bolus dosages of 1 µg/kg IV will be administered if heart rate or mean arterial blood pressure elevated more than 20% of the baseline (after exclusion of other causes than pain).
Time to the 1st rescue analgesia.	24 hours postoperatively	A standardized analgesic regimen will be prescribed in the post-operative period. All patients will receive paracetamol 1 gm every 6 h as routine analgesia. Rescue analgesia of pethidine will be given as 2 mg bolus if the Numerical Rating Scale (NRS) \> 3 to be repeated after 30 min if pain persists until the Numerical Rating Scale (NRS) \< 4. NRS will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.; It will be measured from the end of surgery to first dose of pethidine administrated.
Degree of pain	24 hours postoperatively	Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 represents "no pain" while 10 represents "the worst pain imaginable"). NRS will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.

Trial Locations

Locations (1)

Tanta University; 🇪🇬 Tanta, El-Gharbia, Egypt