Role of host microbiota and multidrug-resistant bacteria in recurrent urinary tract infections
- Conditions
- Recurrent urinary tract infectionsN30Cystitis
- Registration Number
- DRKS00034036
- Lead Sponsor
- niklinik Köln
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 60
rUTI cohort:
- Adult women with recent history of rUTI defined as =3 UTI during the last 12 months or =2 UTI during the last 6 months
- Urogenital anatomical abnormalities allowed in small subgroup (n=5)
Control group: single UTI
- Adult women with symptomatic community-acquired uncomplicated UTI at time of inclusion; symptoms include dysuria, increased urinary frequency and urgency
OR
Adult women with history of single UTI in last 5 years without recurrences afterwards
- Absence of symptoms for alternative urogenital infections including vaginal discharge and vaginal pain at time of UTI presentation
Both groups: Pregnancy
Control group:
- Known anatomical abnormalities in the lower urinary tract
- UTI in previous 6 months
- Antibiotic treatment in previous 3 months
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluate the potential of therapeutic interventions targeting intestinal, vaginal or urinary microbiota for the prevention of rUTI
- Secondary Outcome Measures
Name Time Method - Genomic relatedness of causative uropathogens with intestinal and vaginal bacteria of the same species assessed by WGS<br>- Identification of distinct urinary, vaginal and intestinal microbiota signatures that confer resilience to recurrent disease in women<br>- Investigation of interdependent changes and interactions between urinary and intestinal or vaginal microbiota<br>- Assessment of risk factors for emergence of MDRB as causative pathogens of rUTI