Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary Atherosclerosis
- Conditions
- Acute Coronary Syndrome
- Interventions
- Other: Patients with ACSDevice: MRI
- Registration Number
- NCT02655718
- Lead Sponsor
- Russian Academy of Medical Sciences
- Brief Summary
The purpose of the study is to assess short and long term outcomes of acute coronary syndrome in patients with non obstructive coronary atherosclerosis, to optimize the algorithm for diagnosis and to evaluate its effectiveness
- Detailed Description
The study non randomized, opened, controlled. Cardiovascular Magnetic - resonance imaging reveals both ischemic and non-ischemic causes of acute coronary syndrome. Currently, it is the best method for Imaging and damage assessment of myocardial viability in coronary atherosclerosis and noncoronary injuries (V.Yu.Usov 2012).
Taking into account the results of previous (D. Kawecki, B. Morawiec, P. Monney, 2015) research, it can be concluded that the introduction of cardiovascular magnetic resonance imaging into routine practice will change the structure of morbidity among patients with acute coronary syndrome and non obstructive coronary atherosclerosis . The research was conducted on small groups of patients, and therefore further data acquisition is required.
It is planned to study 200 patients with acute coronary syndrome. On admission, they will receive the standard treatment of ACS with and without ST elevation. Within 72 hours they will performed diagnostic coronary angiography. If in case of non stenotic atherosclerosis of coronary artery (normal / stenosis \< 50%) patients are planned for cardiac contrast MRI, which will identify both ischemic and non-ischemic causes of acute coronary syndrome. At 30 days, 6 months, 12 months the researchers will assess the clinical condition of the patients, perform cardiac ultrasound for the evaluation of myocardial contractile function, evaluate the incidence rate of secondary endpoints
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- age ≥ 18 years at time of randomization (18 years and older)
- acute coronary syndrome
- no obstructive coronary atherosclerosis (normal coronary artety/ plaques <50%) is based on the results of coronary angiography for 3 days of admission
- written the informed consent to participate in research
- patients previously undergone endovascular / surgical revascularization of coronary artery
- severe comorbidity
- Contacts/Locations
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Patients with ACS MRI Patients with ACS who underwent coronary angiography within 72 hours from the onset of disease. In identifying nonobstructive coronary atherosclerosis , patients underwent cardiac contrast MRI. Patients with ACS Patients with ACS Patients with ACS who underwent coronary angiography within 72 hours from the onset of disease. In identifying nonobstructive coronary atherosclerosis , patients underwent cardiac contrast MRI.
- Primary Outcome Measures
Name Time Method Left ventricular ejection fraction (Echo) 14 days after ACS Incidence of inflammatory infiltrate, ischemia, infarction in the myocardial tissue 14 days after ACS
- Secondary Outcome Measures
Name Time Method Incidence of the stroke 6 month and 12 month after ACS Incidence of the acute myocardial infarction 14 days after ACS Incidence of unstable angina 14 days after ACS Incidence of Takotsubo syndrome 14 days after ACS Incidence of myocarditis 14 days after ACS Incidence of the heart failure 6 month and 12 month after ACS Incidence of the mortality 6 month and 12 month after ACS Incidence of the recurrent myocardial infarction 6 month and 12 month after ACS
Trial Locations
- Locations (1)
Research Institutite for Cardiology
🇷🇺Tomsk, Tomskii region, Russian Federation