Potential Impact of Blood Pressure Variability on Right Ventricular Remodeling in Pregnant Women With Pre-eclampsia or Gestational Hypertension
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Aswan University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Number of participants that experienced right ventricular remodeling
Study Overview
Brief Summary
The goal of this observational study is to learn about the potential effect of blood pressure variability changes on right ventricular strain in pregnant women with gestational hypertension or pre-eclampsia
Detailed Description
Hypertensive disorders of pregnancy include chronic hypertension, gestational hypertension, pre-eclampsia and chronic hypertension with superimposed pre-eclampsia. Pre-eclampsia, and all hypertensive disorders affect about 5-10% of pregnancies.
The term Blood Pressure Variability is an entity that characterizes the continuous and dynamic fluctuations that occur in blood pressure levels throughout a lifetime.
It encompasses a wide range of blood pressure variations; occurring over seconds or minutes (very short- term BPV), along 24 hours (short- term BPV, usually assessed by ambulatory BP monitoring), and between days (mid- term or day- to- day BPV, assessed with home BP monitoring), Long-term BPV has also been described, including seasonal BP variations and changes between clinic visits over months or years (visit- to- visit BPV).
Studies showed that visit-to-visit BP variability was associated with gestational hypertension and preeclampsia , as well as with risk of adverse birth outcomes in pregnant women without proteinuria or chronic hypertension.
Preeclampsia is a pregnancy-specific disorder that complicates 2-8% of pregnancies worldwide.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients with ages equal to or more than 18 years old.
- •women with gestational hypertension ( systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg after 20 weeks of gestation without proteinuria ).
- •Women with pre-eclampsia (systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg after 20 weeks of gestation with proteinuria < 300mg /24 h).
Exclusion Criteria
- •Pregnancy less than 20 weeks gestation.
- •Patients with congenital heart diseases.
- •Patients with moderate to severe valvular heart diseases.
- •Patients with cardiomyopathy whatever its cause.
- •Patients with underlying right ventricular dysfunction.
- •Poor image quality.
Outcomes
Primary Outcomes
Number of participants that experienced right ventricular remodeling
Time Frame: From Baseline at time of examination till 3 months post-partum
Assessment of right ventricular strain via 2D Echocardiography and Speckle tracking
Secondary Outcomes
No secondary outcomes reported
Investigators
Mahmoud Elsayed Abdellatif
Cardiology resident
Aswan University