Renal Tubular Disorders in Egyptian Children

Completed

• Conditions: Renal Tubular Disorders in Children

• Registration Number: NCT04845815
• Lead Sponsor: Sohag University

Brief Summary

Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children.

Detailed Description

Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children. As a result, starting management early will help those children have a better life. Therefore awareness about these disorders and long-term outcome is really important. The investigators present the clinical characterizations of many tubular disorder and the follow up in our center.

The aim of this study is to reveal the different clinical presentations and the main lab features of renal tubular disorders in children to promote early recognition and management.

Study Timeline

• Status Verified: 2021-04
• Study First Submitted: 2021-04-12
• Study First Submitted QC: 2021-04-13
• Study First Posted: 2021-04-15
• Study Start: 2021-04-23
• Primary Completion: 2021-12-09
• Study Completion: 2022-01-07
• Last Update Submitted: 2022-01-22
• Last Update Posted: 2022-02-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• All children aged from one month to 18 years who have renal tubular disorders.

Exclusion Criteria

• Children who have renal tubular disorders secondary to drugs, intoxication, obstructive uropathy or transient in nature.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
weight	1 years	in kilograms
Glomerular function	1 years	The glomerular function was assessed by estimated glomerular filtration rate (eGFR) calculated using Schwartz formula. Chronic kidney disease (CKD) was defined in the presence of a permanent reduction in GFR (e-GFR; \<60 ml/min/1.73 m2 Kidney Disease Outcomes Quality Initiative \< stage 3).
height	1 years	in meters

Trial Locations

Locations (1)

pediatric department, Sohag university hospital; 🇪🇬 Sohag, Egypt