NCT03497000已完成不适用
Effects of Optical Coherence Tomography Angiography-guided Photodynamic Therapy in Acute Central Serous Chorioretinopathy
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Number of patients with subretinal fluid resolution on OCT after PDT of two groups
研究概览
简要总结
OCTA-guided PDT is as safe and effective as ICGA-guided PDT in the treatment of acute central serous chorioretinopathy. Or OCTA-guided PDT is more effective than ICGA-guided PDT in the treatment of acute central serous chorioretinopathy, safe as well.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Idiopathic detachment of the neurosensory retina with a focal leak at the level of the RPE with FA
- •Presence of SRF and/or serous pigment epithelial detachment on OCT
- •Presence of abnormal dilated choroidal vasculature in ICGA
排除标准
- •Patients with other ocular conditions commonly associated with SRF, such as choroidal neovascularization, polypoidal choroidal vasculopathy (PCV), diabetic retinopathy, retinal vascular occlusion, Coat's disease
- •Any disease that may affect the quality of imaging (quality of OCTA images < 6), such as cataract, high myopia or nystagmus
- •History of ocular surgeries including retinal laser
- •Pregnancy
- •Any uncontrolled systemic disease
- •Any condition rendering patients intolerable to image acquisition
研究组 & 干预措施
OCTA group
Experimental
Patients in this group underwent OCTA-guided half-dose photodynamic therapy.
干预措施: OCTA-guided Photodynamic therapy (Procedure)
ICGA group
Active Comparator
Patients in this group underwent normal ICGA-guided half dose photodynamic therapy.
干预措施: ICGA-guided Photodynamic therapy (Procedure)
结局指标
主要结局
Number of patients with subretinal fluid resolution on OCT after PDT of two groups
时间窗: 3 months
次要结局
- BCVA (best corrected visual acuity) at every follow-up of two groups(1 month, 3 months)
- Number of patients with leakage point resolution on FFA after PDT of two groups(3 months)
- Number of recurrent CSC after PDT of two groups(3 months)
研究者
Mingwei Zhao
Head of Ophthalmology, Professor
Peking University People's Hospital
研究点 (1)
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