Determination of the minimal clinical important difference (MCID) and its correlation with objective criteria of neuroanatomy in patients with chronic pruritus and dry skin under topical dermatotherapy - Subproject: Identification of relevant genes for neuroanatomy in the skin

• Conditions: L29.9; L28.1; Pruritus, unspecified; Prurigo nodularis

• Registration Number: DRKS00022426
• Lead Sponsor: Klinik für Hautkrankheiten und Kompentenzzentrum Chronischer Pruritus

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-10
• Study Completion: 2022-11-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 57

Inclusion Criteria

Patients with
-Age =18
- clinically visible dry skin on the arm, among other things, chronic pruritus (> 6 weeks duration) on the arm, among other things
- a pruritus intensity NRS bad tester 24h =3
- one of the three diagnoses mentioned:
1) Pruritus patients with chronic scratch lesions (prurigo nodularis) (L28.1)
2) Patients with pruritus on inflammatory skin (e.g. atopic dermatitis) (L 20.9)
3) Patients with pruritus on unchanged skin (L 29.9)

Exclusion Criteria

Acute exacerbation of dermatosis, cutaneous infections
-Pregnancy or breastfeeding
- History of drug use, alcohol addiction, drug abuse
Allergy to local anesthetics,
-tendency to keloids

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of the Minimal Clinically Important Change (MCID)” using the anchor questionnaire and the intensity scales

Secondary Outcome Measures

Name	Time	Method
Correlation of MCID with alloknesis and pruritus threshold and skin nerve anatomy<br><br>Development of two- and three-dimensional cell cultures to investigate the causal meaning of selected candidate genes for neuroanatomy.