Evaluating glucose control before, during and after haemodialysis in patients with diabetes who are using insulin.
- Conditions
- diabetes mellitushaemodialysiscontinuous glucose monitoring
- Registration Number
- NL-OMON20090
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
(1) Abe M, Kaizu K, Matsumoto K. Evaluation of the hemodialysis-induced changes in plasma glucose and insulin concentrations in diabetic patients: comparison between the hemodialysis and non-hemodialysis days. Ther Apher Dial 11, 288-295. 2007.<br> (2) Kazempour-Ardebili S, Lecamwasam VL, Dassanyake T et al. Assessing glycemic control in maintenance hemodialysis patients with type 2 diabetes. Diabetes Care 2009; 32(7):1137-1142.<br> (3) Riveline JP, Teynie J, Belmouaz S et al. Glycaemic control in type 2 diabetic patients on chronic haemodialysis: use of a continuous glucose monitoring system. Nephrol Dial Transplant 2009; 24(9):2866-2871.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
1. Insulin treated diabetes (type 1 or type 2) on haemodialysis;
2. Age =/> 18 years;
1. Secondary form of diabetes;
2. Use of oral hypoglycaemic drugs;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean glucose concentration and area-under-the-curve (AUC) glucose during 24-hour periods, on days with and without haemodialysis.
- Secondary Outcome Measures
Name Time Method 1. Frequency of glucose < 3.5 mmol/L, < 3.0 mmol/L and < 2.5 mmol/L;<br /><br>2. Frequency and severity of self-reported symptomatic hypoglycaemia;<br /><br>3. Correlation between day-to-day variations in physical activity and glucose levels;<br /><br>4. Correlation between day-to-day variations in food intake and glucose levels;<br /><br>5. Elimination rate of insulin and/or glucose during haemodialysis.