Study of invasive fungal mould infections in intensive care units.

Not Applicable

• Conditions: Health Condition 1: null- Invasive mould infections

• Registration Number: CTRI/2016/08/007212
• Lead Sponsor: MERCK SHARP DOHME CORP

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

A patient must fulfill the definition for a case, as given below.

Proven case:Any host whose a) histopathology/ cytology/ direct microscopy demonstrates septate hyphae invading tissue or aspirate from sterile sites b) Culture is positive from sterile sites

Probable case: Host satisfying criteria of EORTC definition/ Host with COPD satisfying definitions by Bulpa P, et al, Eur Resp J 2007;30:782â??800/ Host in ICU satisfying clinical algorithm by Blot SI, et al, Am J Resp Crit Care Med 2012 Apr 19

Exclusion Criteria

Patients with endemic mycoses (histoplasmosis, sporotrichosis, penicilliosis), yeast infections, and allergic fungal diseases like allergic bronchopulmonary aspergillosis will not be included. Infection limited to the skin only will also be excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence and clinical determinants of Invasive mould infections (IMIs) in Indian ICUs will be ascertainedTimepoint: 1 year

Secondary Outcome Measures

Name	Time	Method
To determine the resistance to moulds, specific incidence in different patient groups.Timepoint: 1 year