Intraprocedural Determination of Myocardial Vitality Using Speckle Tracking Echocardiography Compared to Two-time MRI Diagnostics
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Angina Pectoris
- Sponsor
- RWTH Aachen University
- Enrollment
- 130
- Locations
- 1
- Primary Endpoint
- State of health score
- Last Updated
- 10 years ago
Overview
Brief Summary
The investigators will compare myocard vitality diagnostics using 2D-Strain echography and MRI.
Detailed Description
Each patient with typical angina pectoris symptoms will get echocardiographic examination during the inclusion phase. If motion disorder of regional left ventricular myocardial wall is detected, patient will get coronary angiography (not study related, caused of typical angina pectoris symptoms and high probability of CHD). If coronary stenosis related to motion disorder is available, patient will be randomized in two groups during coronary angiography. * First Group: Patient will get echocardiographic examination during coronary angiography. 2D-Strain Analysis will be performed based on data of this echocardiographic examination. Only when vitality in the contraction impaired segments will be established based on 2D-Strain Analysis, PCI (Percutaneous Coronary Intervention) will be performed. * Second Group: Coronary angiography by patient will be canceled. Patients will get viability assessment using MRI(Magnetic resonance imaging) within the next 7 days. When vitality will be established with MRI, patient will get PCI (Percutaneous Coronary Intervention). In addition, as part of a feasibility analysis, the possibility of a consolidation of data of coronary angiography with the ultrasound images will be researched by first group of patients. The aim is to simplify the visualization of the intraprocedural vitality detection. For this purpose, a position sensor based on electromagnetic fields (EMT) will be used during coronary angiography.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Typical angina pectoris symptoms
- •Echocardiographic determination of regional motion disfunction of left ventricular wall
- •Establishment of needly treatment of stenosis related to motion disorder based on coronar angiography.
- •Feasibility of MRI-Examination.
- •Patients which are legally competent and which are mentally able to understand the study staff
- •Patients give their written consent
Exclusion Criteria
- •Allergy against contrast agent
- •Patients with limited renal function(GFR \< 60 ml/min)
- •Acute or instable angina pectoris
Outcomes
Primary Outcomes
State of health score
Time Frame: 6 month after diagnistics
State of health score will be determinated by all patients for the evaluation of clinical outcomes (using the standardized questionnaire on state of health (SF-36))6 months after clinical diagnostics.
Secondary Outcomes
- Left ventricular function (ejection function)(6 month after diagnistics)
- Capture of Major Adverse Cardiac and Cerebrovascular Events(MACCE)(18 month after diagnostics)
- End-diastolic and end-systolic volume.(6 month after diagnostics)