Study on the mechanism of acupuncture for irritable bowel syndrome via brain-gut-intestinal microorganism axis based on fMRI and metagenome

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•(1) IBS patients: ? Meet the Rome III diagnostic criteria of IBS; ? Age 18-70; ? The course of disease is more than 6 months; (4) Lack of morphological changes and biochemical abnormalities that could explain symptoms; ? Did not use any medication for IBS at least 2 weeks before treatment (except emergency treatment); ? Did not receive acupuncture treatment for IBS or psychiatric treatment in the last 3 months, and did not donate blood or participate in clinical trials of other drugs; ? Voluntarily participate in the study and sign the informed consent.
•(2) Healthy subjects: ? Ask about their health status, and perform detailed physical examination (physical examination, electrocardiogram, liver and kidney function, routine hematuria and other laboratory tests) to prove that they are healthy; ? Regular work and rest, no smoking, drug, alcohol abuse history, no drug abuse history. ? Antibiotics were prohibited until the end of the study; ? During the test, the smoking ban, alcohol, tea, coffee and other stimulating drinks should be observed, and fermented dairy products such as yogurt should be prohibited.

•? Patients with alarm symptoms, such as abnormal findings in physical examination, fever, weight loss, blood in the stool, continuous severe abdominal pain lasting more than 12 h/d, acute abdominal pain, etc.;
•? Systemic diseases affecting digestive tract function (such as gallbladder pancreatitis, hyperthyroidism, diabetes, chronic renal insufficiency, neurological diseases);
•(3) Patients with serious primary diseases such as cardiovascular system, liver, kidney, hematopoietic system, mental disease and obvious cognitive dysfunction;
•? Have a history of abdominal or rectoanal surgery;
•? Women during pregnancy, lactation and postpartum =12 months;
•? Metal allergy or severe fear of needles.

发起方

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences