ISRCTN10227738进行中（未招募）未知
Influence of successful periodontal intervention on renal and vascular systems in patients with chronic kidney disease: a pilot interventional randomised controlled trial
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 入组人数
- 77
研究概览
简要总结
2017 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29132440 protocol
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Inclusion criteria for all participants:
- •1. Patient aged =18 years and
- •2. Be able to provide consent to participate in the trial
- •Additional inclusion criteria for patients with CKD and periodontitis:
- •1. Secondary care renal follow up for at least 1 year prior to recruitment
- •2. Decline of eGFR of 5mls/min/year or 10mls/min/5years
- •3. And/or an Albumin Creatinine Ratio (ACR )>70mmol/l on three occasions
- •4. And/or CKD 4 or 5 (pre-dialysis)
- •5. And generalised moderate-severe periodontitis defined as a minimum cumulative probing depth of 30mm (excluding probing depths <5mm)
- •Additional inclusion criteria for systemically healthy patients with periodontitis:
- •1. Generalised moderate-severe periodontitis defined as a minimum cumulative probing depth of 30mm (excluding probing depths <5mm)
排除标准
- •Exclusion criteria for all participants:
- •1. Not meeting the inclusion criteria
- •2. Unable to provide informed consent
- •Additional exclusion criteria for patients with CKD and periodontitis:
- •1. Requiring Renal Replacement Therapy (dialysis/transplant)
- •2. Immunosuppression
- •3. Received specialist periodontal treatment in the past 1 year
- •4. Not amenable to periodontal treatment e.g. severe bleeding disorders that contraindicate periodontal treatment
- •Additional exclusion criteria for systemically healthy patients with periodontitis:
- •1. Any self-reported systemic illness eg hypertension or diabetes
- •2. Received specialist periodontal treatment in the past 1 year
- •3. Not amenable to periodontal treatment e.g. severe bleeding disorders that contraindicate periodontal treatment
- •Additional exclusion criteria for systemically healthy patients without periodontitis:
- •1. Any self-reported systemic illness eg hypertension or diabetes
- •2. Periodontitis defined as probing depth of >4mm at any site
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