Admission HbA1C in Aneurysmal Subarachnoid Hemorrhage

Completed

• Conditions: Hyperglycemia; Aneurysmal Subarachnoid Hemorrhage

• Registration Number: NCT02081820
• Lead Sponsor: Heinrich-Heine University, Duesseldorf

Brief Summary

In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture. In this patient registry admission HbA1c, clinical course and neurological outcome after 6 month are recorded, to determine whether elevated blood glucose levels prior to aneurysm rupture influence the clinical course and patient outcome after aSAH.

Detailed Description

In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture.

In this patient registry admission HbA1c within 72 hours after confirmed aneurysmal subarachnoid hemorrhage in patients aged over 18 years is determined and correlated with clinical course and neurological outcome after 6 month as determined by modified Rankin score. Additionally, patients are monitored for incidence of delayed cerebral ischemia (DCI) and the incidence of new infarction on the discharge ct scan attributable to DCI. General treatment of cerebral aneurysm and subarachnoid hemorrhage in all patients follows international guidelines.

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2014-02-28
• Study First Submitted QC: 2014-03-05
• Study First Posted: 2014-03-07
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-17
• Last Update Posted: 2015-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 89

Inclusion Criteria

• confirmed aneurysmal subarachnoid hemorrhage
• admission within 72hours after hemorrhage
• Age >18 years

Exclusion Criteria

• non-aneurysmal SAH
• admission >72hours after hemorrhage
• Age <18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
modified Rankin score	6 month after discharge

Secondary Outcome Measures

Name	Time	Method
Incidence of DCI related new infarction on discharge ct scan	at discharge, approx. 14-21days after admission	Incidence of new infarction on discharge ct scan not attributable to causes other then DCI.

Trial Locations

Locations (1)

Department of Neurosurgery, Heinrich-Heine-University Düsseldorf; 🇩🇪 Düsseldorf, NRW, Germany