Accuracy of the Pleth Variability Index to Predict Fluid Responsiveness in Liver Transplantation
Phase 4
Completed
- Conditions
- Hemodynamic Instability
- Interventions
- Device: PVI-guided fluid management
- Registration Number
- NCT01792011
- Lead Sponsor
- Inonu University
- Brief Summary
The aim of this study is to compare the accuracy of PVI (pleth variability index)
- Detailed Description
The aim of this study is to compare the accuracy of PVI (pleth variability index)with other hemodynamic variability that measured with PİCCO (SVV, PPV, CVP,CI)to predict the response of cardiac index to volume replacement in patients undergoing liver transplantation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- Elective living donor liver transplantation,
- >18 years patients
Exclusion Criteria
Patients with:
- Arrhythmia
- Reduced left ventricular function (EF<40%)
- Hepatocellular carcinoma
- Pulmonary hypertension
- Fulminant liver failure
- valvular heart disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description PVI PVI-guided fluid management A new non-invasive device (Radical-7 pulse oximeter monitor, Masimo Corp.) has been introduced that continuously detects changes in the plethysmograph waveform and computes a Plethysmography Variability Index (PVI) reflecting alteration in preload and fluid management.
- Primary Outcome Measures
Name Time Method To test the ability of PVI to detect changes in preload during orthotopic liver transplantation During dissection and anhepatic phase (3 months) PVI is a measure of the dynamic changes in perfusion index that occur during a complete respiratory cycle
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation
🇹🇷Malatya, Turkey