Accuracy and Utility of the Pleth Variability Index as a Predictor of Fluid Responsiveness During the Dissection and Anhepatic Phase of Liver Transplantation
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- To test the ability of PVI to detect changes in preload during orthotopic liver transplantation
研究概览
简要总结
The aim of this study is to compare the accuracy of PVI (pleth variability index)
详细描述
The aim of this study is to compare the accuracy of PVI (pleth variability index)with other hemodynamic variability that measured with PİCCO (SVV, PPV, CVP,CI)to predict the response of cardiac index to volume replacement in patients undergoing liver transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective living donor liver transplantation,
- •>18 years patients
排除标准
- •Patients with:
- •Arrhythmia
- •Reduced left ventricular function (EF<40%)
- •Hepatocellular carcinoma
- •Pulmonary hypertension
- •Fulminant liver failure
- •valvular heart disease
研究组 & 干预措施
PVI
A new non-invasive device (Radical-7 pulse oximeter monitor, Masimo Corp.) has been introduced that continuously detects changes in the plethysmograph waveform and computes a Plethysmography Variability Index (PVI) reflecting alteration in preload and fluid management.
干预措施: PVI-guided fluid management (Device)
结局指标
主要结局
To test the ability of PVI to detect changes in preload during orthotopic liver transplantation
时间窗: During dissection and anhepatic phase (3 months)
PVI is a measure of the dynamic changes in perfusion index that occur during a complete respiratory cycle
次要结局
未报告次要终点
研究者
Gulay ERDOGAN KAYHAN
MD,Asistant Professor Dr
Inonu University