Reduction of cerebral air microembolisation improves neuropsychological outcome after pulmonary endarterectomy
Not Applicable
- Conditions
- Chronic thromboembolic pulmonary hypertension,Pulmonary endarterectomy, Postoperative cognitive deficits
- Registration Number
- DRKS00021499
- Lead Sponsor
- Heart and Brain Research Group, Kooperation des Universitätsklinikums Giessen und der Kerckhoff Klinik Bad Nauheim.Gesundheitszentrum Wetterau, Neurologie.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Elelective Pulmonary Endarterectomy
- Patients aged 18 and older
- Informed Consent
- German as mother tongue
Exclusion Criteria
Any pre-existing neurological or psychiatric disease (in particular cerebral infarction, craniocerebral trauma, manifest depression or dementia) that may influence neuropsychological testing
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method As a primary endpoint, we will investigate whether or not the neuropsychological outcome was influenced by the use of the dynamic bubble trap (DBT). For this purpose, the neuropsychological outcome will be measured preoperatively and 3 months after surgery with a detailed, objective, neuropsychological test battery.
- Secondary Outcome Measures
Name Time Method As secondary endpoints, subjective self- and foreign assessment of cognitive deficits, anxiety and depression as well as health-related quality of life will be assessed preoperatively and 3 months after surgery using standardized questionnaires. Postoperative cerebral micro-infarcts will be measured 6-10 days after surgery by diffusion-weighted MRI. The number of microemboli before and after the DBT will be measured with a gas bubble counter.