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Clinical Trials/NCT05924152
NCT05924152CompletedPhase 1

A Phase 1, Open-label, One-sequence Crossover Study to Investigate the Effect of a Breast Cancer Resistance Protein Inhibitor on the Single-dose Pharmacokinetics of Adagrasib in Healthy Adult Subjects

Mirati Therapeutics Inc.1 site in 1 country16 target enrollmentStarted: June 29, 2023Last updated:
Conditions
Interventions
Drugs

Trial Snapshot

Phase
Phase 1
Status
Completed
Enrollment
16
Locations
1
Primary Endpoint
Pharmacokinetics - Cmax (adagrasib)

Study Overview

Brief Summary

A Phase 1, Open-label, One-sequence Crossover Study to Investigate the Effect of a Breast Cancer Resistance Protein Inhibitor on the Single-dose Pharmacokinetics of Adagrasib in Healthy Adult Subjects

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Crossover
Primary Purpose
Other
Masking
None

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Males or females, of any race, between 18 and 60 years of age, inclusive, at Screening.
  • Body mass index between 18.0 and 32.0 kg/m2, inclusive, at Screening.
  • In good health, determined by no clinically significant findings from medical history, physical examination, 12-lead ECG, vital sign measurements, or clinical laboratory evaluations at Screening and Check-in as assessed by the Investigator.
  • Females of childbearing potential will not be pregnant or lactating and must have a negative result on an approved pregnancy test at Screening and Check-in. Females of childbearing potential must agree to use contraception.
  • Male subjects must agree to use contraception.
  • Able to comprehend and willing to sign an informed consent form (ICF) and to abide by the study restrictions.

Exclusion Criteria

  • Significant history or clinical manifestation of any metabolic, allergic, dermatological, renal, hematological, thrombotic, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder, as determined by the Investigator.
  • History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, any components of the investigational product (IP), or other substance (not including seasonal allergies).
  • History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions (eg, uncontrolled nausea, vomiting, malabsorption syndrome).
  • Significant history or clinical manifestation of any hepatic disease, as determined by laboratory abnormalities.
  • History or current diagnosis of uncontrolled or significant cardiac disease indicating significant risk of safety for participation in the study.
  • Ventricular dysfunction or history of risk factors for Torsades de Pointes.
  • History of drug abuse within 2 years prior to Screening.
  • History of alcohol abuse within 12 months prior to Screening.
  • Positive serology test results for hepatitis B surface antigen, hepatitis C antibody, and/or human immunodeficiency virus (HIV) 1/
  • Use of tobacco- or nicotine-containing products within 3 months prior to Check-in.
  • Use of any drugs or substances known or suspected to alter drug absorption, distribution, metabolism, or elimination.
  • Use or intend to use any prescription medications/products within 14 days prior to Check-in.
  • Use or intend to use any nonprescription medications/products including vitamins, minerals, and phytotherapeutic/herbal/plant-derived preparations.
  • Participation in a clinical study involving administration of an investigational drug (new chemical entity) in the past 30 days.
  • Subjects who, in the opinion of the Investigator, should not participate in this study.

Arms & Interventions

Treatment A

Active Comparator

Treatment A: A single oral dose of adagrasib 400 mg (2 × 200-mg tablets) on Day 1;

Intervention: Adagrasib (Drug)

Treatment B

Active Comparator

Treatment B: A single oral dose of eltrombopag 75 mg

(1 × 75-mg tablet) plus adagrasib 400 mg (2 × 200-mg tablets) on Day 8.

Intervention: Eltrombopag + adagrasib (Drug)

Outcomes

Primary Outcomes

Pharmacokinetics - Cmax (adagrasib)

Time Frame: Days 1 and 8

Maximum observed plasma concentration (Cmax)

Pharmacokinetics - AUC (adagrasib)

Time Frame: Days 1 and 8

AUC from time zero to the last quantifiable concentration (AUClast)

Pharmacokinetics - t1/2 (adagrasib)

Time Frame: Days 1 and 8

Elimination half-life (t1/2)

Pharmacokinetics - Tmax (adagrasib)

Time Frame: Days 1 and 8

Time to reach Cmax (tmax)

Pharmacokinetics - CL/F (adagrasib)

Time Frame: Days 1 and 8

Apparent total plasma clearance (CL/F)

Pharmacokinetics - Vz/F (adagrasib)

Time Frame: Days 1 and 8

Apparent volume of distribution (Vz/F)

Secondary Outcomes

  • Adverse Events (AEs)(Up to 8 weeks from screening)

Investigators

Sponsor Class
Industry
Responsible Party
Sponsor

Study Sites (1)

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