The Amplitude of Auditory Evoked Potentials and the Intensity of Experimental Pain Stimulation in Healthy Volunteers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- Odense University Hospital
- Enrollment
- 20
- Primary Endpoint
- VAS and amplitude of AEP
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
Monitoring of auditory evoked potentials (AEP) in patients during general anaesthesia is commonly used to ensure a sufficient hypnotic level during surgery. The amplitude of AEP (AEPa) has in clinical settings been found to correlate to pain. The aim of the study was to test, if AEPa could detect increasing experimental pain stimulations in healthy volunteers. Electric nerve stimulation, cold and heat pain were used as pain models.
Detailed Description
During the AEP monitoring, healthy volunteers were exposed to experimental pain. At study day 1: Firstly, single electric nerve stimulation and repetitive electric nerve stimulations causing temporal pain summation. The stimulations were given at 50, 75 and 100% of the thresholds for pain tolerance and temporal pain summation. Secondly, the volunteers were exposed to cold pain by use of two different Cold Pressor Tests (CPT) with water temperatures at 8 and 1 Celsius. All measurements were repeated after an hour to test reproducibility. At study day 2: Brief Thermal Stimulation were used with two different temperatures and duration.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 20 - 40 years old
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
VAS and amplitude of AEP
Time Frame: before, during and after experimental pain
Secondary Outcomes
- reproducibility(after an hour)