Complications of High Frequency Jet Ventilation
- Conditions
- High-Frequency Jet VentilationBronchoscopy
- Interventions
- Procedure: High frequency jet ventilation
- Registration Number
- NCT06285994
- Lead Sponsor
- Erasme University Hospital
- Brief Summary
High frequency jet ventilation (HFJV) has been introduced in 1967 as technique allowing ventilation with simultaneous access to the airway for bronchoscopy. Continuous improvement in the technique has led to a large use during interventional bronchoscopy, especially in large centers. However, complications occuring during the use of HFJV are poorly known. In this retrospective cohort study, the charts of all patients who had a bronchoscopy with the use of HFJV between 2019 and 2023 in our hospital will be analyzed. Primary outcome will the description of all complications during HFJV. Complications are defined as:
* Hypoxia: SpO2 \< 90% for 1 min
* Severe hypoxia: SpO2 \< 85% for 1 min
* Hemodynamic instability, defined as Arterial pressure \< 90/60
* Cardiac arrhythmia
* Laryngospasm or bronchospasm
* Barotrauma or volutrauma
* Need for ICU admission
A model predicting the risk for developing any complication will be developped using 2 mathematical methods:
* a multivariate analysis
* a data mining approach
For both approaches, the following variables will be included in the model:
* Age
* Gender
* Weight
* Height
* BMI
* Smoking
* Alcohol consumption
* Consumption of Other drugs
* ASA class
* Obstructive pulmonary disease
* Restrictive lung disease
* COPD status (1, 2, 3, 4)
* Interstitial lung disease
* Lung tumor
* Trachea location
* Carina location
* Bronchial location
* Pulmonary or tracheal stenosis
* Presence of stridor
* Severe stenosis (\< 6 mm)
* Baseline SpO2 (pre-intervention)
* Pre-intervention oxygen requirement Procedure
* Duration (min)
* Stent placement
* Dilation
* Laser treatment
* Length of hospital stay Lung function tests
* FEV1 (forced expiratory volume)
* VC (Vital Capacity)
* FEV1/VC (Tiffeneau ratio)
* CPT (total lung capacity)
* DLCO (carbon monoxide diffusion)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1385
- All patients who underwent a bronchoscopy with the use of high frequency jet ventilation between January 1st, 2019 and December 31st, 2023 at Erasme University Hospital, Brussels
- Incomplete medical chart
- Patient who expressed their opposition to the use of their medical data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description HFJV High frequency jet ventilation All patients who underwent bronchoscopy with the use of high frequency jet ventilation between January 1st 2019 and december 31st 2023.
- Primary Outcome Measures
Name Time Method Occurence of complications 6 hours The occurence (%) of complications of HFJV will be analyzed. Definition of complications is one or more of the following events:
* Hypoxia: SpO2 \< 90% for 1 min (%)
* Severe hypoxia: SpO2 \< 85% for 1 min (%)
* Hemodynamic instability, defined as Arterial pressure \< 90/60 (%)
* Cardiac arrhythmia (%)
* Laryngospasm or bronchospasm (%)
* Barotrauma or volutrauma (%)
* Need for ICU admission (%)
Complications will be reported as overall complications (%) defined as the occurence of one or more of the listed events.
Frequency of single events will be reported separately (%). Descriptive statistics ( %, mean, standard deviation, median, interquartile range) will be used as appropriate.
- Secondary Outcome Measures
Name Time Method Prediction model of complications 6 hours A model predicting the risk for developing any complication will be developped using 2 mathematical methods:
* a multivariate analysis
* a data mining approach
Trial Locations
- Locations (1)
Hôpital Universitaire de Bruxelles - Hôpital erasme
🇧🇪Brussels, Belgium