The Effects of End-tidal Controlled Low-Flow Anesthesia on Anesthetic Agent Consumption in Elective Surgeries
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Gaziantep
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Serum thiol-disulfide homeostasis parameters measurement/ calculation
Study Overview
Brief Summary
This study aimed to compare the effects of sevoflurane and desflurane used in low-flow anesthesia on thiol-disulfide homeostasis of patients undergoing general anesthesia.
Detailed Description
Fifty patients were included who were scheduled to undergo elective total thyroidectomy operation under general anesthesia. The patients were assigned to one of 2 groups. Group S was the low-flow sevoflurane anesthesia group and Group D was the low-flow desflurane group. Blood samples were collected to evaluate thiol disulfide homeostasis preoperatively and postoperatively.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Other
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients who were scheduled to undergo elective total thyroidectomy under general anesthesia
Exclusion Criteria
- •Patients with diabetes mellitus, alcohol or drug addiction, smoking habits, expected difficult intubation, morbid obesity, chronic obstructive pulmonary disease, cardiovascular disease and those in pregnancy or lactation period were excluded from the study.
Arms & Interventions
sevoflurane
sevoflurane low-flow anesthesia
Intervention: low-flow anesthesia (Procedure)
sevoflurane
sevoflurane low-flow anesthesia
Intervention: A 5 cc venous blood sample was obtained (Other)
desflurane
desflurane low-flow anesthesia
Intervention: A 5 cc venous blood sample was obtained (Other)
desflurane
desflurane low-flow anesthesia
Intervention: low-flow anesthesia (Procedure)
Outcomes
Primary Outcomes
Serum thiol-disulfide homeostasis parameters measurement/ calculation
Time Frame: A 5 cc venous blood sample was obtained just before the anesthesia induction and at the end of surgery.
Serum thiol-disulfide homeostasis parameters were evaluated using an automated method (3). Homeostasis parameters include disulfide, native thiol (NT) and total thiol (TT) levels, and disulfide/TT, NT/TT, and disulfide/NT ratios. TT and NT levels were measured in μmol/L on a Beckman Coulter AU480 analyzer using a commercial kits (Rel Assay Diagnostics, Türkiye). The amount of disulfide was calculated using the formula ((TT-NT) /2). Then, ratios were calculated as percentages
Secondary Outcomes
No secondary outcomes reported
Investigators
Elzem SEN
Assoc. Prof.
University of Gaziantep