Effect of Oxytocin Infusion on Blood Loss During Abdominal Myomectomy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Blood loss during surgery
研究概览
简要总结
To evaluate the effects of oxytocin infusion during abdominal myomectomy.
详细描述
Myomectomy is indicated for symptomatic uterine fibroids. Fibroids have blood supply and 20% of the abdominal myomectomy cases might require blood transfusion because of the nature of the surgery. Oxytocin infusion is one of the intervention to decrease blood loss during myomectomy. To evaluate the effects and benefits of oxytocin infusion during abdominal myomectomy we decide to conduct this randomized study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
盲法说明
Randomization will be performed by an online software and the list will be given to anesthesiologist so that neither the surgeon nor patient will know which intervention was performed. Randomized cards will be in sealed envelopes and will be open by anesthesiologist at the time of surgery.
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 18-50
- •Patients who are candidate for abdominal myomectomy
排除标准
- •History of previous myomectomy.
- •Suspected malignancy
- •Patients with preoperative anemia
- •Patients using hormonal treatments before the surgery.
研究组 & 干预措施
Oxytocin infusion
Patients will receive intravenous oxytocin infusion just before the surgery after the induction of general anesthesia.
干预措施: Oxytocin (Drug)
Placebo
Patients will receive pure normal saline infusion at the same rate and volume just before the surgery after the induction of general anesthesia.
干预措施: saline (Other)
结局指标
主要结局
Blood loss during surgery
时间窗: 2 hours
estimated blood loss during the surgery measured by aspiration fluid.
次要结局
- Blood loss after abdominal myomectomy(1 hour postoperatively)
研究者
Berna Aslan Cetin
Attending physician,ObGyn
Kanuni Sultan Suleyman Training and Research Hospital