euroinflammation in frontotemporal lobar degeneration: a multimodal biomarker study

Recruiting

Conditions: dementia and parkinsonism
10028037
10012272

Registration Number: NL-OMON54174

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 110

Inclusion Criteria

- Ability to undergo MRI scanning
- For probable FTLD-tau: a clinical diagnosis of PSP, CBS or nfvPPA, or any
clinical FTLD spectrum diagnosis with a proven MAPT mutation
- For probable FTLD-TDP: a clinical diagnosis of svPPA or any clinical FTLD
spectrum diagnosis with a proven GRN mutation or C9orf72 repeat expansion
- For presymptomatic mutation carriers: a MAPT mutation, GRN mutation or a
C9orf72 mutation withouth clinical sign of a FTLD spectrum phenotype (CDR 0)
- For control subjects: no known neurological or psychiatric disorder

Exclusion Criteria

- Other neurological or psychiatric disorder that may affect cognitive
functions, such as a brain tumour, multiple sclerosis or drug or alcohol abuse
or use of psycho-active medications
- CSF profile (β-amyloid, p-tau, t-tau) suggestive of AD pathology
- Clinical dementia Rating Scale (CDR) score >1
- Contra-indication to undergo MRI
- Contra-indication to undergo lumbar puncture

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences between patients with FTLD-TDP, patients with FTLD-tau in the<br /><br>symptomatic and presymptomatic stage and healthy controls in CSF and MRI<br /><br>measures for neuroinflammation and correlation with clinical measures at<br /><br>baseline and follow-up. </p><br>

Secondary Outcome Measures