NCT01570660已完成不适用
Effects of Glimepiride Monotherapy Versus Combined Neteglinide-Pioglitazone Therapy on Insulin Sensitivity in Type 2 Diabetic Patients
German Diabetes Center1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2002年2月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- whole body insulin sensitivity
研究概览
简要总结
Thiazoledinediones decrease blood glucose by their insulin-sensitizing properties. Here the investigators examined whether pioglitazone (PIO) improves insulin sensitivity independently of glycemic control and whether adipokines or non-esterfied fatty acids (NEFA) serve as mediators.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •well controlled patients with type 2 diabetes (Hb1Ac < 8%)
- •no insulin therapy
- •no co-morbidities
- •stable medication use for the last 6 months
- •stable body weight the last 6 months
- •no diet in the last 6 months
排除标准
- •Hb1Ac > 8%
- •insulin therapy
- •diabetes-related co-morbidities, like cardiovascular disease, neuropathology
- •unstable medication use
- •unstable body weight in the last 6 months (> 5 kg)
- •following a diet in the last 6 months
研究组 & 干预措施
control group
No Intervention
parallel group without intervention
干预措施: Pioglitazone (Drug)
结局指标
主要结局
whole body insulin sensitivity
时间窗: within a minimal of 1 week before the start of the 12 weeks pioglitazone or glimepiride treatment and after the last day of the treatment period.
Participants underwent a two-step hyperinsulinemic euglycemic clamp to determine insulin sensitivity, expressed as rate of glucose disposal (Rd) in mg/kg/min.
次要结局
- intrahepatocellular lipid content(within a minimal of 1 week before the start of the 12 weeks pioglitazone or glimepiride treatment and after the last day of the treatment period.)
研究者
研究点 (1)
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