Peanut protein detection in serum and exercise

Completed

• Conditions: intestinal permeability; nutrient absorption; 10017943; 10001708

• Registration Number: NL-OMON43051
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- 20-35 year old male or female
- Body mass index (BMI) 23-27.5 kg/m2
- Suitable veins for blood sampling
- No inhibitory matrix effect in Ara h6 ELISA method
- Able to cycle 1h on ergometer

Exclusion Criteria

- History of peanut allergy
- Known symptoms of immune disease, such as diabetes, gastritis, and coeliac disease.
- Pregnant or lactating
- Known symptoms of intestinal disease, such as Crohn*s Disease, ulcerative colitis, and irritable bowel syndrome.
- Smoking
- Use of hard drugs
- Use of specific medicines:
o Chronic use of NSAIDs: aspirins, ibuprofen, etc.
o Drugs having an effect on gastric and/or intestinal function and motility, including antidepressants.
- Participation in other scientific studies
- Blood donation during the last six weeks before the start and during the study
- Employed at Human Nutrition, Human and Animal Physiology, or Consumer Science and Health(FBR) or performing an internship/thesis at any of these places.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the serum Ara h6 level after intake of peanuts with and<br /><br>without exercise</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary outcome is the lactulose/rhamnose ratio in plasma after intake of<br /><br>the dual sugar solution with and without exercise</p><br>