The Effects of Morphine on Desflurane Consumption and Recovery Time
- Registration Number
- NCT02362022
- Lead Sponsor
- Baskent University
- Brief Summary
Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
- undergoing total abdominal hysterectomy with general anaesthesia
Exclusion Criteria
- renal dysfunction (cre>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group Morphine 1 Morphine Group Morphine 1 (Group M1) received i.v morphine 0.1 mg kg-1, in 10 ml volume (n=30) Group Saline Morphine Group Saline (Group S) received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 2 Morphine Group Morphine 2 (Group M2) received i.v morphine 0.2 mg kg-1, in 10 ml volume (n=30)
- Primary Outcome Measures
Name Time Method postoperative desflurane consumption postoperative first hour sedation scores for OASS scale postoperative first hour
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Baskent University School of Medicine Adana Teaching and Research Hospital
🇹🇷Adana, Turkey