Comparison of Two Different Doses of Intravenous Morphine on Desflurane Consumption and Recovery Time in Patients Undergoing Total Abdominal Hysterectomy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- postoperative desflurane consumption
研究概览
简要总结
Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Care Provider, Investigator)
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •undergoing total abdominal hysterectomy with general anaesthesia
排除标准
- •renal dysfunction (cre>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders
研究组 & 干预措施
Group Saline
Group Saline (Group S) received i.v saline 0.9 % in 10 ml volume (n=30)
干预措施: Morphine (Drug)
Group Morphine 1
Group Morphine 1 (Group M1) received i.v morphine 0.1 mg kg-1, in 10 ml volume (n=30)
干预措施: Morphine (Drug)
Group Morphine 2
Group Morphine 2 (Group M2) received i.v morphine 0.2 mg kg-1, in 10 ml volume (n=30)
干预措施: Morphine (Drug)
结局指标
主要结局
postoperative desflurane consumption
时间窗: postoperative first hour
sedation scores for OASS scale
时间窗: postoperative first hour
次要结局
未报告次要终点
研究者
CAGLA BALI,MD
medical doctor
Baskent University