Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 2
- 主要终点
- Hemodynamic features assessed by echocardiography before the volemic expansion of cirrhotic patients with acute renal injury corresponding to the criteria of hepatorenal syndrome.
研究概览
简要总结
This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome. This echocardiography will be done before the volemic expansion and the final diagnostic of hepatorenal syndrome or prerenal azotemia. The primary endpoint is to describe the hemodynamic characteristics of this population at the time of acute kidney injury and their association with diagnostic of hepatorenal syndrome or prerenal azotemia. Patients with elevated filling pressure, predicting poor outcome of volemic expansion will be excluded of the study after the echocardiography and will not undergo volemic expansion but appropriate management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients > 18 years
- •written consent for the participation of the study
- •cirrhosis with portal hypertension and ascite
- •acute kidney injury according to AKIN criteria (rapid increase of creatinine (48 hours) > 26.4 µmol or > 50% comparing with baseline). Baseline creatinine is the last value of creatinine before admission or creatinine at the admission if stable during 5 days.
- •absence of argument for acute tubular necrosis or other organic acute renal injury
- •absence of argument for shock
排除标准
- •pregnant women
- •volemic expansion before echocardiography
- •portal thrombosis
- •presence of TIPSS
- •history of cardiac or renal pathology
- •atrial fibrillation
- •cardiac valvulopathy
- •technical limitation due to echogenicity
研究组 & 干预措施
cirrhosis with portal hypertension,ascite and acute kidney
干预措施: Echocardiography (Procedure)
结局指标
主要结局
Hemodynamic features assessed by echocardiography before the volemic expansion of cirrhotic patients with acute renal injury corresponding to the criteria of hepatorenal syndrome.
时间窗: At Day0 : at the time of diagnostic of acute kidney injury, before volemic expansion.
Systolic and diastolic function assessment, filling pressures, pulmonary arterial hypertension
次要结局
- Tolerance of volemic expansion, as recommended by international guidelines(After 48 hours of volemic expansion)
- Response to vasoconstrictor treatment of hepatorenal syndrome, in case of diagnostic of hepatorenal syndrome(1 month after inclusion)
- Mortality(1 month after inclusion)