Incidence of active tuberculosis in latent tuberculosis infection end stage kidney disease patients waiting for kidney transplant treated with isoniazid and rifapentine 1 month
- Conditions
- ESRD patients on waiting list for kidney transplant who was tested IGRA with positive result.Latent tuberculosis infection, transplantation, end stage kidney disease, isoniazid, rifapentine
- Registration Number
- TCTR20211213004
- Lead Sponsor
- Division of nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 260
Inclusion Criteria
1. Age >= 18 years old
2. Normal chest X-ray within 90 days
3. Body weight >= 35 kg
4. Laboratory investigations revealed
- AST and ALT < 3 x ULN
- Total bilirubin < 1.5 mg/d
Exclusion Criteria
1. Has sign or symptoms of active tuberculosis
2. During treatment of active tuberculosis
3. History of active tuberculosis treatment within 2 years
4. History of latent tuberculosis treatment within 2 years
5. History of isoniazid or rifampicin/rifapentine resistace
6. Cirrhosis
7 . Pregnancy or during breast feeding
8. HIV infection
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of active tuberculosis disease End of study Incidence
- Secondary Outcome Measures
Name Time Method Prevalence of latent tuberculosis infection Day 0 Prevalence