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Clinical Trials/NCT04098614
NCT04098614
Completed
Not Applicable

Barriers to Substance Use Disorder Recovery

Prisma Health-Upstate1 site in 1 country99 target enrollmentSeptember 3, 2019

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Substance Use Disorders
Sponsor
Prisma Health-Upstate
Enrollment
99
Locations
1
Primary Endpoint
Change in Inhibitory Control
Status
Completed
Last Updated
last year

Overview

Brief Summary

The study purpose is to investigate how an inpatient recovery coaching intervention can overcome or mitigate specific risk factors and barriers to initiating and maintaining Substance Use Disorder recovery. This study will offer insight into how and why an inpatient link to recovery coaching is effective for promoting long-term Substance Use Disorder recovery.

Detailed Description

Substance Use Disorder (SUD) is a prevalent disease that impacts an estimated 24 million Americans each year. The life-altering consequences of SUD are both diverse and severe, influencing mortality, the workplace, and economics. The goal of this study is to determine how specific risk factors of relapse and barriers to recovery, including neurocognitive, health, personal, social, financial, and situational barriers, can be overcome or changed through a recovery coaching intervention. This work seeks to provide a mechanism to demonstrate exactly how and why this potential new model of care (recovery coaching) is effective, rather than simply assessing if it can work. To accomplish this aim, the change between baseline and 6-month assessments will be assessed. Then, the difference in the change between individuals assigned to the current standard of care and patients assigned to inpatient recovery will be compared.

Registry
clinicaltrials.gov
Start Date
September 3, 2019
End Date
December 18, 2020
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Prerana Roth

Clinical Assistant Professor

Prisma Health-Upstate

Eligibility Criteria

Inclusion Criteria

  • Age 18 - 60
  • English speaking;
  • Identified by healthcare provider as having Substance Use Disorder
  • Recent substance use
  • Currently admitted to the Medical Teaching Services, general medicine hospitalist services, or Infectious Disease Consult service at Greenville Memorial Hospital

Exclusion Criteria

  • Are unable to provide informed consent (intubation, confusion, etc.) during hospitalization
  • Are admitted for marijuana use only
  • Are admitted for cocaine use only
  • Are pregnant

Outcomes

Primary Outcomes

Change in Inhibitory Control

Time Frame: baseline and 6 months post-baseline assessment

Inhibitory control will be assessed behaviorally using a 150 - 200 trial computerized 'Stop Signal' Task, the most common measure of this construct. Stop Signal Reaction Time (SSRT) and Stop trial accuracy will be measured and compared across time points.

Change in Risk-Taking

Time Frame: baseline and 6 months post-baseline assessment

Risk-taking will be measured using the 7-item Risk Propensity Scale (Meertens \& Lion, 2008). Higher scores on this scale indicate greater risk-taking propensity.

Change in Social Support

Time Frame: intervals of 1, 2, 3, and 6 months post-baseline assessment

Participants will complete the 5-item Social Support subscale of the Assessment of Recovery Capital (ARC) to assess social support. The difference between the post-baseline and baseline measures will be assessed.

Change in Financial Barriers to SUD Recovery

Time Frame: intervals of 1, 2, 3, and 6 months post-baseline assessment

These barriers include lack of stable housing, transportation, and cost of recovery services. Participants will complete the Housing and Safety Subscale of the Assessment of Recovery Capital (ARC) to assess social support and housing stability. The difference between the post-baseline and baseline measures will be assessed.

Change in Resting State EEG beta poewer

Time Frame: baseline and 6 months post-baseline assessment

We will measure both absolute and relative powers for beta (14-25 Hz) bands using a 24-channel Soterix Medical EEG.

Change in Striatal Dopaminergic Functioning

Time Frame: baseline and 6 months post-baseline assessment

Consistent with previous research, we will assess average spontaneous eyeblink rate, a well-validated indirect proxy for available levels of striatal tonic dopamine.

Change in Situational Barriers to SUD Recovery

Time Frame: intervals of 1, 2, 3, and 6 months post-baseline assessment

The barriers measured will be (1) long delays for treatment, (2) complexity of navigating the healthcare system, (3) lack of programs in one's community, (4)lack of professional help, (4) and not knowing where to go for help. The response options are binary (yes, they think this is a barrier to their recovery', or 'no, not a barrier to recovery'). Responses to these questions (0=no, 1=yes) will be summed to determine situational barriers. The difference between the post-baseline and baseline measures will be assessed.

Change in Emotion Regulation

Time Frame: baseline and 6 months post-baseline assessment

The Emotion Regulation Questionnaire (ERQ-10) will be used to assess these emotion regulation strategies and skills.

Change in Goal-Related Activities

Time Frame: baseline and 6 months post-baseline assessment

Participants will complete the 5-item Meaningful Activities from the Assessment of Recovery Capital questionnaire. The 5 items will be summed for a total score.

Secondary Outcomes

  • Engagement in Recovery Services(intervals of 1, 2, 3, and 6 months post-baseline assessment)
  • Hospital Visit Frequency(six months pre- and post-baseline assessment)
  • Emotional Well-being(intervals of 1, 2, 3, and 6 months post-baseline assessment)
  • Life Satisfaction(intervals of 1, 2, 3, and 6 months post-baseline assessment)
  • Substance Use Severity(intervals of 1, 2, 3, and 6 months post-baseline assessment)

Study Sites (1)

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