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临床试验/NCT03212794
NCT03212794已完成不适用

Initiating Substance Use Disorder Treatment for Hospitalized Opioid Use Disorder Patients.

Brigham and Women's Hospital2 个研究点 分布在 1 个国家目标入组 29 人开始时间: 2019年2月11日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
29
试验地点
2
主要终点
Treatment Retention

研究概览

简要总结

The purpose of this 24-week study is to evaluate the impact of recovery coach intervention on rates of treatment retention, illicit opioid use, and readmission among hospitalized patients newly initiated on buprenorphine or methadone compared to the control intervention.

详细描述

Patients with opioid use disorder (OUD) frequently utilize hospitals due to soft tissue infections and other conditions that require inpatient level of care. Prior studies have indicated that OUD patients are often amenable to initiating buprenorphine treatment and can be successfully linked to outpatient treatment. However, hospitalized OUD patients initiated on buprenorphine have much lower treatment retention rates at 6-months compared to OUD patients initiating treatment in the outpatient setting. As such, there is a great need to identify strategies to improve treatment retention in this patient population. There is a growing body of evidence for the benefits of recovery coaches, who provide peer-delivered support services in the community. Tracing their origin to mutual support groups to supplement traditional clinical services, recovery coaches are individuals with lived experience of recovery. Studies of recovery coaches have demonstrated greater treatment retention, reduced substance use, and reduced inpatient utilization. However, no prior studies have examined the impact of recovery coaches in improving medication-assisted treatment retention. As such, the aim of this 24-week study is to evaluate the impact of recovery coach intervention on rates of treatment retention, illicit opioid use, and readmission among hospitalized patients newly initiated on buprenorphine or methadone compared to the control intervention. Patients who are successfully initiated on buprenorphine or methadone, and are willing to engage in treatment after discharge, will be eligible to enroll. Assessments will be conducted at baseline, 4 weeks, 12 weeks, and 24 weeks.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • English speaking, adults aged 18-75
  • Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) diagnosis of opioid use disorder, severe, actively using illicit opioids until the time of hospitalization
  • Have a working telephone
  • Can identify at least 2 individuals who can act as points of contact following discharge from the hospital
  • Willing to engage in treatment (either a psychosocial treatment program AND/OR medication treatment with methadone or buprenorphine)

排除标准

  • Liver function test >3x upper normal limit
  • Psychotic disorder, active suicidality or homicidality
  • Condition likely to be terminal in 24 weeks such as cancer
  • Unable to perform consent due to mental status
  • Engaged in substance abuse treatment in the last month prior to admission

结局指标

主要结局

Treatment Retention

时间窗: 24 weeks after baseline

Primary outcome was retention in MOUD treatment at 6-months after discharge. If referred to programs affiliated with Brigham and Women's Hospital (BWH), the electronic health records were used to confirm treatment retention. Otherwise, retention was determined through self-report or confirmation with collateral contacts. If the electronic health record was not available for confirmation and the participant was lost to follow-up, the missing data was imputed as discontinuation of MOUD treatment.

次要结局

  • Readmissions(24 weeks after baseline)
  • Days to Hospital Readmission(24 weeks after baseline)
  • Days to Treatment Discontinuation(24 weeks after baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Joji Suzuki, MD

Director, Division of Addiction Psychiatry

Brigham and Women's Hospital

研究点 (2)

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