Inspiratory muscle training prior to peripheral muscle training in patients adolescents with Cystic Fibrosis.

Completed

• Conditions: 10028302; 10010613; cystic fibrosis

• Registration Number: NL-OMON38371
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

•Ambulant patients with CF
•Age: range from 12 to 18 years of age

Exclusion Criteria

- Acute gastro-intestinal or pulmonary exacerbation (extra oral or intravenous antibiotics for the past four weeks) at inclusion.
- Oxygen saturation (SpO2) < 90% (without O2 supply)
- Ineligible to perform CPET
- not familiar with the Dutch language
- Pneumothorax

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The peak work rate in watts (Wpeak) achieved during the aerobic maximal<br /><br>exercise test (CPET).<br /><br>The main study parameter of the alternative protocol is the * time recovery of<br /><br>phosphocreatine (1/2 time PCr recovery) after maximal exercise.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- work of breathing in rest and during exercise<br /><br>- exercise capacity (except Wpeak)<br /><br>- disease specific and generic Health Related Quality of Life<br /><br>- habitual daily activity<br /><br>- respiratory muscle function<br /><br>- peripheral muscle function<br /><br>- rate of perceived exertion<br /><br>- patient specific goals<br /><br>- co morbidity<br /><br>- spirometry<br /><br>- anthropometry<br /><br>- use of medication and other care<br /><br>- compliance to interventions<br /><br>- feasibility of interventions and measurements<br /><br>- type of CF gene mutation</p><br>