High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure

Not Applicable

Completed

• Conditions: Respiratory Insufficiency
• Interventions: Other: Pulmonary Function Testing & esophageal pressure monitoring; Other: Pulmonary function testing and esophageal pressure

• Registration Number: NCT01531465
• Lead Sponsor: Christiana Care Health Services

Brief Summary

The purpose of this study is to compare two common methods of providing respiratory support: nasal continuous airway pressure and high flow nasal cannula to see what effect it has on babies breathing. The investigators also will compare the effects of slightly changing the level of support these two different types of therapy on how easily your baby is breathing. Changes in the level of support and between these two respiratory support modalities are frequently done and are part of the routine care in the neonatal intensive care unit.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-05-25
• Study Start: 2011-06
• Study First Submitted QC: 2012-02-08
• Study First Posted: 2012-02-13
• Primary Completion: 2012-10
• Study Completion: 2013-01
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-03
• Last Update Posted: 2013-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Infants who are between 28 and 40 weeks of corrected gestational age at the time of study entry
• Currently on high flow nasal cannula receiving 3 to 5 lpm or on nasal continuous positive airway pressure at 5 to 6 cmH2P with and FiO2 requirement </= 40% by the clinical care team for clinical care purposes.
• On current mode of support for >/= 12 hours and have been extubated from a mechanical ventilator for >/= 48 hours.

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Exclusion Criteria

• Infants with skeletal or neuromuscular disorders that affect the accuracy of RIP PFT measurements.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
NCPAP to HFNC	Pulmonary Function Testing & esophageal pressure monitoring	Infants who are currently on NCPAP.
HFNC to NCPAP	Pulmonary function testing and esophageal pressure	Infants who are currently on HFNC.

Primary Outcome Measures

Name	Time	Method
lung compliance	2 hours	Is there a difference in pulmonary function tests in infants with respiratory insufficiency being treated with high flow nasal cannula (HFNC) or nasal continuous positive airway pressure (NCPAP)?

Trial Locations

Locations (1)

Christiana Care Health System - Christiana Hospital; 🇺🇸 Newark, Delaware, United States