Pulmonary Function Testing in Infants With Respiratory Insufficiency While Receiving High Flow Nasal Cannula (HFNC) Versus Nasal Continuous Positive Airway Pressure (nCPAP)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- lung compliance
Study Overview
Brief Summary
The purpose of this study is to compare two common methods of providing respiratory support: nasal continuous airway pressure and high flow nasal cannula to see what effect it has on babies breathing. The investigators also will compare the effects of slightly changing the level of support these two different types of therapy on how easily your baby is breathing. Changes in the level of support and between these two respiratory support modalities are frequently done and are part of the routine care in the neonatal intensive care unit.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 2 Days to 6 Months (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •* Infants who are between 28 and 40 weeks of corrected gestational age at the time of study entry
- •* Currently on high flow nasal cannula receiving 3 to 5 lpm or on nasal continuous positive airway pressure at 5 to 6 cmH2P with and FiO2 requirement \/= 12 hours and have been extubated from a mechanical ventilator for \>/= 48 hours.
Exclusion Criteria
- •Infants with skeletal or neuromuscular disorders that affect the accuracy of RIP PFT measurements.
Arms & Interventions
HFNC to NCPAP
Infants who are currently on HFNC.
Intervention: Pulmonary function testing and esophageal pressure (Other)
NCPAP to HFNC
Infants who are currently on NCPAP.
Intervention: Pulmonary Function Testing & esophageal pressure monitoring (Other)
Outcomes
Primary Outcomes
lung compliance
Time Frame: 2 hours
Is there a difference in pulmonary function tests in infants with respiratory insufficiency being treated with high flow nasal cannula (HFNC) or nasal continuous positive airway pressure (NCPAP)?
Secondary Outcomes
No secondary outcomes reported