Evaluating the Effectiveness of Memantine on the Symptoms of Acute Mania in the Patients with Bipolar 1 Disorder

Not Applicable

• Conditions: Bipolar I disorder.; Bipolar affective disorder, current episode hypomanic

• Registration Number: IRCT2016121725031N6
• Lead Sponsor: Vice Chancellor for Research of Arak University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Between 18 to 60 years old; Meet the criteria for bipolar disorder based on DSM-1V-TR diagnostic criteria and clinical interview by a psychiatrist; Existence of mania, with a minimum score of 20 in Young Mania Rating Scale; Lack of psychiatric diseases; Without mental retardation; Lack of any disease that make a problem in the clinical study; Do not consume narcotic, stimulants and alcohol except nicotine in the three last months; Do not electroconvulsive therapy in the previous month; Not pregnant; Without drug allergy and drug side effects history on the this study drugs; Do not consume memantine in the three last months; Lack of dementia, delirium, cognitive disorders and epilepsy. Exclusion criteria: Drugs side effect that causing discontinuation of consume them; Request by the patient or the patient's parent or legal guardian to withdraw from the study at any time of the study; Consume of alcohol or narcotic by the patient after starting the study; Lack of response to the drug therapy after 2 weeks.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical symptoms of mania. Timepoint: At the beginning of treatment, second week, forth week and eighth week. Method of measurement: Young Mania Rating Scale Measure.